Tufts Vascular Neurology Research Group
I lead the TVNR group, a clinical research team focused on epidemiological research questions related to stroke and other cerebrovascular diseases. Our primary areas of interest are:
  • Stroke in young adults
  • Late complications after ischemic stroke and intracerebral hemorrhage in stroke survivors
  • The role of migraine in the pathogenesis of brain ischemia
  • Silent brain infarcts and the prevention of stroke and dementia
Our methodologies include registry-based cohort and case control studies, semi-structured qualitative interviews, quantitative surveys, regression analyses, and predictive modeling.

We collaborate frequently with the Predictive Analytics and Comparative Effectiveness (PACE) Center at Tufts Medical Center and the Center for Outcomes Research & Evaluation (CORE) at Maine Medical Center.

Recent work from TVNR
Invited Talks, Posters, and Presentations
  • Poster for the International Stroke Conference, Los Angeles, 2016: Leung LY, Caplan LR. “Factors associated with delay in presentation to the hospital for young adults with ischemic stroke.”

  • Poster for the American Academy of Neurology Meeting, Vancouver, 2016: Leung LY et al. “Factors influencing oral anticoagulant prescribing for atrial fibrillation.”

  • Poster for the American Academy of Neurology Meeting, Vancouver, 2016: Leung LY, Caplan LR. “Factors associated with delay in presentation to the hospital for young adults with ischemic stroke.”

  • Poster for the International Stroke Conference, Houston, 2017: Leung LY, et al. “Blood pressure and heart rate measures associated with increased risk for silent brain infarction and worsening leukoaraiosis in older adults.”

  • Poster for the American Academy of Neurology Meeting, Boston, 2017: Huggins H, Jones D, Thaler DE, Han PKJ, Leung LY. “Clinical features of acute stroke in young adults – a qualitative study of patient experiences.”

  • Poster for the American Academy of Neurology Meeting, Boston, 2017: Jones D, Huggins H, Thaler DE, Han PKJ, Leung LY. “Barriers and facilitators for seeking care for young adults with acute stroke – a qualitative study.”

  • Poster for the American Academy of Neurology Meeting, Boston, 2017: Albazli K, Wu S, Kent D, Leung LY. “Silent brain infarction and symptomatic stroke: comparing imaging and patient characteristics.”

  • Poster for the European Stroke Organization Conference, Prague, 2017: Leung LY, Han PKJ, Lundquist C, Weinstein G, Thaler DE, Kent D. “Silent brain infarction – assessing clinical decision making.”

  • Poster for the International Stroke Conference, Honolulu, 2019: Michaels E, Leung LY. “Associations between risk factors and mechanisms of stroke in young adult stroke.”

  • Poster for the International Stroke Conference, Honolulu, 2019: Skeels K, Leung LY. “Two-part intervention to improve transitions of care for stroke patients.”

  • Poster for the American Academy of Neurology Meeting, Philadelphia, 2019: Huggins H, Brady M, Thaler DE, Leung LY. “Differences in presenting symptoms of acute stroke among young and older adults.”


Publications
  • Leung LY, Caplan LR. “Factors associated with delay in presentation to the hospital for young adults with ischemic stroke.” Cerebrovascular Diseases. 2016;42(1-2):10-14. PMID: 26953591.

  • Leung LY, McAllister ML, Selim M, Fisher M. “Factors influencing oral anticoagulant prescribing for atrial fibrillation.” Journal of Stroke. 2017 May;19(2):232-235. PMID: 28460492. PMCID: PMC5466293.

  • Leung LY, Melkumova E, Thaler DE. “Longitudinal care for young adults with stroke.” JAMA Neurol. 2017 Oct1;74(10):1163-1164. PMID: 28828467.

  • Leung LY, Bartz TM, Rice K, et al. “Blood pressure and heart rate measures associated with increased risk of covert brain infarction and worsening white matter in older adults.” Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1579-1586. PMID: 28663254. PMCID: PMC5551454.

  • Smith EE, Kent DM, Bulsara KR, Leung LY, Lichtman JH, Reeves MJ, Towfighi A, Whiteley WN, Zahuranec DB; American Heart Association Stroke Council.. Effect of Dysphagia Screening Strategies on Clinical Outcomes After Stroke: A Systematic Review for the 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke. Stroke. 2018 Jan 24. [Epub ahead of print] doi: 10.1161/STR.0000000000000159. PMID: 29367332.

  • Smith EE, Kent DM, Bulsara KR, Leung LY, Lichtman JH, Reeves MJ, Towfighi A, Whiteley WN, Zahuranec DB; American Heart Association Stroke Council.. Accuracy of Prediction Instruments for Diagnosing Large Vessel Occlusion in Individuals With Suspected Stroke: A Systematic Review for the 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke. Stroke. 2018 Jan 24. [Epub ahead of print] doi: 10.1161/STR.0000000000000160. PMID: 29367333.
  • Leung LY, Han PKJ, Lundquist C, Weinstein G, Thaler DE, Kent D. “Clinicians’ perspectives on incidentally discovered silent brain infarction – a qualitative study.” PLOS One. 2018;13(3):e0194971. PMID: 29596459.

  • Fu S, Leung LY et al. “Natural language processing for the identification of silent brain infarcts from neuroimaging reports.” Journal of Medical Internet Research. 2019;7(2):e12109. PMID: 31066686.

  • Ridha M, Malek A, Arkun K, Leung LY. “The utility of histopathologic characteristics of thrombi in large vessel occlusions.” Neurology Clinical Practice. In press.

  • Leung LY, Han PKJ, Lundquist C, Weinstein G, Thaler DE, Kent D. “Patients’ perspectives on incidentally discovered silent brain infarction – a qualitative study.” Journal of Patient-Reported Outcomes. 2019;3(1):23. PMID: 30982930. PMCID: PMC6462438.

  • Mccarty, J, Leung LY, et al. “Different Strokes, Younger Folks: An Image-Based Review of Ischemic Infarction in Young Adults.” Radiographics. In press.

TVNR Members
Lester Y. Leung, MD, MSc - PI

2016
Khaled Albazli, MD
Dylan Jones, MS, MPH
Pierre Martin, MD

2017
Nick Cunningham, MD
Sharon Wu, MD
Nilufer Yalcin, MD

2018
Merrill Brady, MD
Sarah Gans
Haley Huggins
Elena Michaels
Katelyn Skeels, NP

2019
Yasaman Adibnia, MD